Wenjian Gan Lab - Ubiquitination in cancer stem cell: roles and

Journal article

Liu Liu, Shasha Yin, Charles Brobbey, W. Gan
2020

Cite

APA Click to copy
Liu, L., Yin, S., Brobbey, C., & Gan, W. (2020). Ubiquitination in cancer stem cell: roles and targeted cancer therapy.

Chicago/Turabian Click to copy
Liu, Liu, Shasha Yin, Charles Brobbey, and W. Gan. “Ubiquitination in Cancer Stem Cell: Roles and Targeted Cancer Therapy” (2020).

MLA Click to copy
Liu, Liu, et al. Ubiquitination in Cancer Stem Cell: Roles and Targeted Cancer Therapy. 2020.

BibTeX Click to copy

@article{liu2020a,
  title = {Ubiquitination in cancer stem cell: roles and targeted cancer therapy},
  year = {2020},
  author = {Liu, Liu and Yin, Shasha and Brobbey, Charles and Gan, W.}
}

Abstract

Cancer stem cells (CSCs) are a small subset of stem-like cells inside tumors, which possess abilities of unlimited self-renewal, differentiation and proliferation. Extensive studies have suggested that CSCs are one of the major drivers of tumor initiation, metastasis, relapse and therapeutic resistance. Several regulatory networks including transcriptional programs and various signaling pathways tightly control the stemness, proliferation and differentiation of CSCs. Emerging evidence has indicated that post-translational modifications, especially ubiquitination, play a critical role in maintenance of CSC properties. In this review, we summarize current understandings on E3 ubiquitin ligase-mediated regulation of transcription factors and key signaling pathways involved in the regulation of CSCs, and discuss the strategy to target CSCs and E3 ubiquitin ligases for combating cancers.