PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.
Anitha Vijayakumar, Mrinmoyee Majumder, Shasha Yin, Charles Brobbey, Joseph Karam, B. Howley, Philip H Howe, Stefano Berto, Lalima K. Madan, Wenjian Gan, Viswanathan Palanisamy
Nucleic Acids Research, 2024
Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer
Charles Brobbey, Shasha Yin, Liu Liu, L. Ball, P. Howe, J. Delaney, W. Gan
Scientific Reports, 2023
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
Shasha Yin, Liu Liu, L. Ball, Yalong Wang, M. Bedford, S. Duncan, Haizhen Wang, W. Gan
Cell Reports, 2023
Haizhen Wang, Yu Zhou, C. Chu, Jialing Xiao, Shanshan Zheng, M. Korpal, Joshua M. Korn, Tiffany Penaloza, Richard R Drake, W. Gan, Xueliang Gao
Molecular Cancer Research, 2023
TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner
Liu Liu, Shasha Yin, W. Gan
Cancers, 2023
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
Liu Liu, Baicheng Lin, Shasha Yin, L. Ball, J. Delaney, David T. Long, W. Gan
Science Advances, 2022
Liu Liu, Xiaoming Dai, Shasha Yin, Pengda Liu, Elizabeth G. Hill, Wenyi Wei, W. Gan
Science Signaling, 2022
PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining
Shasha Yin, Liu Liu, W. Gan
Genome Instability & Disease, 2022
The Role of Protein Arginine Methyltransferases in DNA Damage Response
Charles Brobbey, Liu Liu, Shasha Yin, W. Gan
International Journal of Molecular Sciences, 2022
Genetic fusions favor tumorigenesis through degron loss in oncogenes
Jing Liu, Collin J Tokheim, Jonathan D. Lee, W. Gan, Brian J. North, Shirley Liu, P. Pandolfi, Wenyi Wei
Nature Communications, 2021
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, L. Ball, S. Olsen, Michael C. Ostrowski, W. Gan
Nature Communications, 2021
The Roles of Post-Translational Modifications on mTOR Signaling
Shasha Yin, Liu Liu, W. Gan
International Journal of Molecular Sciences, 2021
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
W. Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jian-ping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, J. Asara, P. Pandolfi, Yingzi Yang, Zhigang He, G. Gao, Wenyi Wei
Nature Cell Biology, 2020
Ubiquitination in cancer stem cell: roles and targeted cancer therapy
Liu Liu, Shasha Yin, Charles Brobbey, W. Gan
2020
Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1
Wantae Kim, Y. Cho, Xiaohui L. Wang, Ogyi Park, Xueyan Ma, Hanjun Kim, W. Gan, E. Jho, B. Cha, Yunsuk Jeung, Lei Zhang, B. Gao, Wenyi Wei, Jin Jiang, K. Chung, Yingzi Yang
Proceedings of the National Academy of Sciences of the United States of America, 2019
PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
Jinfang Zhang, Yu-Ru Lee, Fabin Dang, W. Gan, Archita V. Menon, Jesse Katon, Chih-Hung Hsu, J. Asara, Priyanka Tibarewal, N. Leslie, Yang Shi, P. Pandolfi, Wenyi Wei
Cancer Discovery, 2019
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
Jinfang Zhang, Ming Chen, Yasheng Zhu, Xiangpeng Dai, Fabin Dang, Junming Ren, S. Ren, Yulia V. Shulga, F. Beca, W. Gan, Fei Wu, Yu-Min Lin, Xiaobo Zhou, J. Decaprio, Andy H. Beck, K. Lu, Jiaoti Huang, C. Zhao, Yinghao Sun, Xu Gao, P. Pandolfi, Wenyi Wei
Developmental Cell, 2019
Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions
Jian-ping Guo, Xiangpeng Dai, B. Laurent, Nana Zheng, W. Gan, Jian Zhang, A. Guo, Min Yuan, Pengda Liu, J. Asara, A. Toker, Yang Shi, P. Pandolfi, Wenyi Wei
Nature Cell Biology, 2018
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
Pengda Liu, W. Gan, Siyuan Su, Arthur V. Hauenstein, T. Fu, B. Brasher, C. Schwerdtfeger, A. Liang, Ming Xu, Wenyi Wei
Science Signaling, 2018
The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li, Xiangyuan Liu, Min Chen, Huairui Yuan, Xiaopeng Xie, Qingrun Li, Yuxue Zhang, H. Ouyang, Mengqi Wei, J. Huang, Pengda Liu, W. Gan, Yong Liu, Anyong Xie, Xiao-ling Kuai, G. Chirn, Hu Zhou, Rong Zeng, Ronggui Hu, Jun Qin, Fei-Long Meng, Wenyi Wei, H. Ji, Daming Gao
Nature Cell Biology, 2018
Jianjun Zhang, Jian-ping Guo, X. Qin, Bin Wang, Linli Zhang, Yingnan Wang, W. Gan, P. Pandolfi, Wantao Chen, Wenyi Wei
Science Signaling, 2018
Fei Wu, Xiangpeng Dai, W. Gan, L. Wan, Min Li, N. Mitsiades, Wenyi Wei, Q. Ding, Jinfang Zhang
Cancer Letters, 2017
Xiangpeng Dai, W. Gan, Xiaoning Li, Shangqian Wang, Wei Zhang, Ling Huang, Shengwu Liu, Q. Zhong, Jian-ping Guo, Jinfang Zhang, Ting Chen, K. Shimizu, F. Beca, Mirjam Blattner, Divya Vasudevan, Dennis L. Buckley, J. Qi, Lorenz Buser, Pengda Liu, H. Inuzuka, Andrew H. Beck, Liewei Wang, P. Wild, L. Garraway, M. Rubin, C. Barbieri, Kwok-kin Wong, S. Muthuswamy, Jiaoti Huang, Yu Chen, J. Bradner, Wenyi Wei
Nature Network Boston, 2017
The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168
Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li, Xiangyuan Liu, Min Chen, Huairui Yuan, Xiaopeng Xie, Qingrun Li, Yuxue Zhang, H. Ouyang, Mengqi Wei, Jing Huang, Pengda Liu, W. Gan, Yong Liu, Anyong Xie, Xiao-ling Kuai, G. Chirn, Hu Zhou, Rong Zeng, Ronggui Hu, J. Qin, Fei-Long Meng, Wenyi Wei, H. Ji, Daming Gao
Nature Cell Biology, 2017
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Bin Wang, Bin Wang, Zuliang Jie, Donghyun Joo, A. Ordureau, Pengda Liu, W. Gan, Jian-ping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, X. Bian, Lingqiang Zhang, J. Harper, Shao Cong Sun, Wenyi Wei
Nature, 2017
Linli Zhang, S. Peng, Xiangpeng Dai, W. Gan, Xin Nie, Wenyi Wei, G. Hu, Jian-ping Guo
Cancer Letters, 2017
Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.
Jinfang Zhang, Kai Xu, Kai Xu, Pengda Liu, Y. Geng, Bin Wang, Bin Wang, W. Gan, Jian-ping Guo, Fei Wu, Fei Wu, Y. R. Chin, C. Berrios, Evan C. Lien, A. Toker, J. Decaprio, P. Sicinski, Wenyi Wei
Molecules and Cells, 2016
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
Jian-ping Guo, A. Chakraborty, Pengda Liu, W. Gan, Xingnan Zheng, H. Inuzuka, Bin Wang, Jinfang Zhang, Linli Zhang, Min Yuan, Jesse S. Novak, J. Cheng, A. Toker, S. Signoretti, Qing Zhang, J. Asara, W. Kaelin, Wenyi Wei
Science, 2016
Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.
Pengda Liu, W. Gan, Chunguang Guo, Anyong Xie, Daming Gao, Jian-ping Guo, Jinfang Zhang, Nicholas A. Willis, A. Su, J. Asara, R. Scully, Wenyi Wei
Molecules and Cells, 2015
Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF
W. Gan, Pengda Liu, Wenyi Wei
The Nucleus, 2015
Cell cycle status dictates effectiveness of rapamycin
W. Gan, Pengda Liu, Wenyi Wei
Cell Cycle, 2015
-Dependent Activation of the mTORC2 Kinase Complex
Pengda Liu, W. Gan, Y. R. Chin, K. Ogura, Jian-ping Guo, Jinfang Zhang, Bin Wang, J. Blenis, L. Cantley, A. Toker, Bing Su, Wenyi Wei
2015
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Pengda Liu, W. Gan, Y. R. Chin, K. Ogura, Jian-ping Guo, Jinfang Zhang, Bin Wang, J. Blenis, L. Cantley, A. Toker, B. Su, Bing Su, Wenyi Wei
Cancer Discovery, 2015
W. Gan, Xiangpeng Dai, A. Lunardi, Zhen Li, H. Inuzuka, Pengda Liu, Shoreh Varmeh, Jinfang Zhang, Liang Cheng, Yin Sun, J. Asara, Andy H. Beck, Jiaoti Huang, P. Pandolfi, Wenyi Wei
Molecules and Cells, 2015
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu, M. Begley, W. Michowski, H. Inuzuka, M. Ginzberg, Daming Gao, P. Tsou, W. Gan, Antonella Papa, B. Kim, L. Wan, Amrik J Singh, B. Zhai, Min Yuan, Zhiwei Wang, S. Gygi, T. Lee, K. Lu, A. Toker, P. Pandolfi, J. Asara, M. Kirschner, P. Sicinski, L. Cantley, Wenyi Wei
Nature, 2014
Pengda Liu, Jian-ping Guo, W. Gan, Wenyi Wei
Protein & Cell, 2014
Pengda Liu, W. Gan, H. Inuzuka, A. Lazorchak, Daming Gao, O. Arojo, Dou Liu, L. Wan, B. Zhai, Yonghao Yu, Min Yuan, B. Kim, S. Shaik, Suchithra Menon, S. Gygi, T. Lee, J. Asara, B. Manning, J. Blenis, B. Su, Wenyi Wei
Nature Cell Biology, 2013
Y. Kanehiro, K. Todo, Misaki Negishi, Junji Fukuoka, W. Gan, Takuya Hikasa, Y. Kaga, Masayuki Takemoto, M. Magari, Xialu Li, J. Manley, H. Ohmori, N. Kanayama
Proceedings of the National Academy of Sciences of the United States of America, 2012
R-loop-mediated genomic instability is caused by impairment of replication fork progression.
W. Gan, Zhishuang Guan, Jie Liu, T. Gui, K. Shen, J. Manley, Xialu Li
Genes & Development, 2011
Na Qu, W. Gan, Dongling Bi, Shitou Xia, Xin Li, Yuelin Zhang
2010